Antagoniści receptora angiotensynowego (ARB) są jednymi z leków pierwszego rzutu w terapii nadciśnienia tętniczego. U większości pacjentów z nadciśnieniem konieczne jest odpowiednio dobrane leczenie skojarzone, które często najlepiej jest prowadzić za pomocą preparatów złożonych. W niniejszej pracy omówiono rolę, jaką w praktyce klinicznej może odgrywać nowoczesny, długo działający lek z grupy ARB – kandesartan, a także preparaty złożone będące połączeniem kandesartanu i hydrochlorotiazydu lub amlodypiny.
Dokonano przeglądu dowodów z badań klinicznych z zastosowaniem kandesartanu, a także oceniono względną wartość tego leku na tle konkurencyjnych ARB. Zarówno kandesartan, jak i jego preparaty złożone umożliwiają skuteczne, bezpieczne i dobrze tolerowane leczenie hipotensyjne, które może być z powodzeniem stosowane u większości pacjentów z nadciśnieniem, niezależnie od ich dodatkowej charakterystyki klinicznej, profilu metabolicznego, czynników ryzyka, powikłań nadciśnienia oraz chorób współistniejących.
Autor: dr n. med. Piotr Jędrusik
Data publikacji: 2015-06-17
Źródło: Lek w Polsce 04/2015
Słowa kluczowe: kandesartan, antagonista receptora angiotensynowego, amlodypina, hydrochlorotiazyd, nadciśnienie tętnicze, niewydolność serca, preparaty złożone, leczenie nadciśnienia
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